This year's ABRF-ASBMB educational symposium was held May 31, 1993. The session began with approximately 450 people in attendance. Bill Hancock from Genentech opened with a discussion of the use of mass spectrometry to verify the structure of and identify post-translational modifications present on biologically active proteins designed for therapeutic use. He presented several strategies for structural analysis, since even correctly prepared proteins can present complex spectra. Pamela Stanley (Albert Einstein) spoke about "glycosylation engineering", her approach to placing defined carbohydrate structures on mammalian glycoproteins. Details on the design and screening of mutants in CHO cells were given. Ellson Chen from Applied Biosystems described the state of the art of DNA sequencing on the scale required for large projects such as the human genome project. Bruce Erickson (Univ. North Carolina) presented his work on "nongenetic protein engineering", the synthesis of model peptides and proteins with novel structural features. Ron Niece (Univ. Wisconsin) closed the session with highlights from the new ABRF survey of core facility laboratory options.
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