created: 14th January 1998, last updated: 14th January 1998, © 1998 ABRF
The primary function of peptide synthesis facilities should be to insure that the correct peptide has been synthesized and delivered in the requested form. If a peptide is found to be incorrectly synthesized, steps should be taken to determine the nature of the problem to prevent recurrence. The purpose of this year's study is to assess the ability of and determine the means whereby member facilities identify and solve problems in peptide synthesis. The two test peptides for the 97-98 study have been made and characterized by amino acid analysis, sequence analysis, elution on high pressure liquid chromatography, electrospray mass spectrometry, and matrix-assisted laser desorption spectrometry. The two test peptides (1 mg each) were sent to participants in September. The participants were given the peptide sequence and asked to determine if the correct peptide has been made, and if not, what would be the next step performed if this peptide had been synthesized in their facility. All results are reported by code number to insure confidentiality. The study is still open and test peptides can be requested by contacting :
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