Dear All!
I have been asked by a researcher in my insititute, to assess the
feasibility of introducing an aldehyde moiety into a short 8 a.a. sequence.
This modified peptide would need to be subsequently conjugated to a larger
macromolecule. I am trying to identify which process would be the best to
carry out this synthesis, and keep the reactivity of the peptide intact for
the subsequent conjugation. Whether to start with aromatic or aliphatic
aldehyde compounds? Or try to use protecting groups which could be removed
after conjugation to the macromolecule? Our peptide contains several
asparagines and a phenylalanine, therefore solubility is an issue. If
somebody has attempted similar experiments or has any suggestions, I would
appreciate your feedback.
JL
Dr. Jan Lukszo
Peptide Analysis and Synthesis Unit
NIH/NIAID/OSD/SBS
Twinbrook II
12441 Parklawn Drive
Rockville, MD 20852
phone:(301)496-3786
fax:(301)480-2618
E-Mail: lukszo@ncisun1.ncifcrf.gov
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