Lisa:
Both ways - injection (e.g. intraperitoneal for mice) and oral, have
been reported to be effective in antisense oligo delivery, see for
example
Wang H, Cai Q, Zeng X, Yu D, Agrawal S, Zhang R. Antitumor activity and
pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted
to the RIalpha subunit of protein kinase A after oral administration.
Proc Natl Acad Sci U S A. 1999,96,13989-13994.
Regards,
victor
www.alphadna.com
______________________
Lisa Bibbs wrote:
I have a basic question. How do antisense oligos get into the cell
to do their job in an animal?
I was having a discussion with a friend and I know how they are
designed to do their job, but how do they get there? Orally?
injection? how?
Thanks,
Lisa
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