You might like to try 'solid phase adsorption on to charcoal', Sahal &, J.
Pept. Sc. vol53, p91, 1999 to remove iodine. -- NLB.
At 04:06 PM 3/9/00 -0600, you wrote:
>We are planning on performing iodine oxidation in solution to form a
>disulfide bond from a peptide with 2 Cys(Acm) groups. I have 2 questions
>regarding this:
>
>1. Will the iodine treatment disturb an existing disulfide bond in the
>peptide?
>
>2. Can you share a protocol for removing the iodine after oxidation is
>complete (prior to HPLC purification)?
>
>Thanks for your help.
>
>
>Randy Wilhelm
>Sr. Research Chemist
>Mallinckrodt, Inc
>Discovery Research Peptide Team
>Phone (314)654-3965
>Fax (314)654-8911
>rrwilhe@mkg.com
>
>
N. Leo Benoiton Professor Emeritus
Department of Biochemistry,
University of Ottawa, Tel: 613 562 5800 ext. 8216
451 Smyth Road, Fax: 613 562 5440
Ottawa, Ontario, Canada K1S 3M6 eMail: benoiton@uottawa.ca
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