Functional Genomics at Cambridge University
Funded by the BBSRC Investigating Gene Function initiative, the Departments
of Biochemistry and Genetics are establishing functional genomics service
resources for the UK Arabidopsis and Drosophila research communities. The
new facilities will include a centre for Proteomics analysis, Microarray
expression studies and new Drosophila mutant collections. To staff these
new units we have to following positions immediately available:
3 Senior Research Associates Starting Salary £27,451*
3 Postdoctoral Research Associates Salary £16,286 - £24,479
11 Senior Research Laboratory Technicians Salary £13,595 - £16,721
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Proteomics: Housed in the Department of Biochemistry, the proteomics
facility will give Arabidopsis and Drosophila researchers access to a wide
range of proteomics resources, including analysis of protein samples with
2D gels and protein identification through MALDI and electrospray mass
spectrometry on state-of-the-art equipment. The unit will be lead by an
experienced Senior Research Associate and be staffed by 2 postdoctoral
researchers and 4 senior technicians.
The Senior Research Associate (Unit Manager) will have experience in 2D gel
electrophoresis and significant proficiency in mass spectrometry. Ideally,
scientific skills will include an in-depth knowledge of protein chemistry
and subpicomole-level sample handling, operation and maintenance of HPLC,
robotic and mass spectrometry instrumentation, and interpretation of
resulting data. S/he will be expected to formulate and carry out a
programme of development within the proteomics unit aimed at improving and
optimising sample handling, separation and analysis at the subpicomole
level. The successful applicant will be considered for re-appointment to
the retiring age after the first three years.
A postdoctoral researcher is required to carry out 2D gel electrophoresis
and analysis of images, assisted by two senior technicians. The candidate
should be proficient in gel running and staining and will be expected to
contribute significantly to a programme of study into the acquisition and
evaluation of quantitative data arising from gel analysis.
A second postdoctoral researcher will carry out mass spectrometry to
identify proteins, assisted by two senior laboratory technicians (Posts
BE126 and BE126A). Candidates should be experienced in MALDI and
electrospray mass spectrometry and will contribute to the development of
improved techniques for protein and peptide analysis within the unit. A
high level of competence in computer skills would be an significant
advantage.
Two further senior technicians (Posts BE125 and BE125A) will carry out
protein sample preparation, 2D gel electrophoresis and use of computers,
robotic sample preparation, and mass spectrometers for protein
identification. Applicants for the technician positions should have
experience in careful handling of proteins, and have an HNC (biological
science) or equivalent experience.
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Microarrays: Housed in the Department of Genetics, the Microarray
expression facility will provide high throughput DNA handling and
Microarray expression services to the UK Drosophila community, including
the generation, hybridisation and analysis of glass slide microarrays. The
unit will be headed by a Senior Research Associate and staffed by a
postdoctoral researcher and four senior technicians.
The Senior Research Associate will assume overall responsibility for the
establishment and development of resources, including the generation and
analysis of DNA microarrays, the development of RNA labelling methodologies
and the establishment of a high throughput DNA handling facility. There
will be scope for the development of an independent research programme.
The postdoctoral researcher will be responsible for the development of RNA
labelling methodologies and will assist in the generation and analysis of
microarrays.
Four senior technical support staff (Posts GC79, GC79A, GC80 and GC81) are
required to assist in the generation and analysis of DNA Microarrays and
the high throughput sequence mapping of transposon inserts.
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Bioinformatics: Bioinformatics support will be required to implement and
develop tools for the analysis and web publication of Microarray gene
expression data and Proteomics data.
We have available a position at the Senior Research Associate level for a
candidate with appropriate molecular biology or computing skills. The
platform for developing computing resources is flexible; however,
familiarity with Windows98/NT, Java and XML would be advantageous.
Drosophila Genetics: Housed in the Department of Genetics, the unit will
generate new P-element insert mutant collections. The Genetics unit will
collaborate closely with the Microarray unit to facilitate the rapid
mapping of new P-element insertions.
We have positions for 3 senior research technicians (Posts GC77, GC77A and
GC78) to generate and maintain the P-element collections and participate in
the molecular mapping of the insertions. Applicants should have experience
of Drosophila genetics.
-------------------------------------------------
Applications: Applications are invited from all suitably qualified persons;
starting salaries are dependent upon age and experience. With the
exception of the post of Proteomics Unit Manager all these posts have
limits of tenure initially. In the cases of GC77 and GC77A the limit is 28
February 2005; in the cases of BE125, BE125A, BE126 and BE126A it is 31
December 2002 (from 1 June 2000); in all the other cases it is three years.
They may, subject to the availability of funding, be renewed for a further
period or periods.
* It is expected that applicants for the three senior positions will have
extensive research and development experience in the relevant field. For
the Proteomics and Microarray unit managers we expect that candidates will
possess experience in personnel management, and administration. Salary
will be in Research Grade II range; however, salaries could be in a higher
range, funded by supplements from the Isaac Newton Trust, dependant upon
the development of an appropriate independent research programme.
Candidates should submit a C.V. and details of at least two referees.
Applicants for the Research Associate posts will be expected to have a PhD
in molecular biology. Candidates should submit a C.V. and details of at
least two referees.
Applicants for the senior research technician posts should have relevant
research experience, and have an HNC (biological science) or equivalent and
appropriate experience. Application forms and job descriptions for each
of these posts should be obtained from the appropriate contact, detailed
below.
For further information on the Proteomics positions contact Dr Paul Dupree,
Department of Biochemistry, Tennis Court Road, Cambridge CB2 1QW
(pd101@cam.ac.uk) or Professor David Glover, Department of Genetics,
Downing Street, Cambridge, CB2 3EH (d.m.glover@gen.cam.ac.uk). Application
forms and job descriptions for the technical posts can be obtained from Mrs
Maureen Brooks, Department of Biochemistry, Building O, Tennis Court Road,
Cambridge CB2 1QW, tel: 01223-333616 (mb226@mole.bio.cam.ac.uk) to whom
formal applications for all posts should be addressed.
For the Microarray, Bioinformatics and genetics positions contact Dr.
Steven Russell, Department of Genetics, Downing Street, Cambridge, CB2 3EH
(s.russell@gen.cam.ac.uk). Application forms and job descriptions for the
technical posts can be obtained from Mrs Tracy Oakley, Departmental
Secretary, Department of Genetics, Downing Street, Cambridge, CB2 3EH, tel:
01223-333987 (t.oakley@gen.cam.ac.uk) to whom formal applications for all
posts should be addressed.
The closing date for all applications is 14 April 2000.
*********************************************************************
Dr Len C. Packman
Assistant Director of Research
Protein and Nucleic Acid Chemistry Facility
Department of Biochemistry
University of Cambridge
80 Tennis Court Road
Old Addenbrookes Site
Cambridge, CB2 1GA, UK
Tel: +44 (1223) 333639
FAX: +44 (1223) 766002
e-mail: lcp2@mole.bio.cam.ac.uk
Visit my WWW page at http://www.bio.cam.ac.uk/proj/adr/PNAC/pnac.html
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