Acetonitrile for Nanocapillary MS

From: Rod McCoy (mccoy@pcg.wustl.edu)
Date: Thu Apr 13 2000 - 11:50:18 EDT


Hello!

Does anyone have suggestions for which brands and lots of Acetonitrile
are optimal for minimal chemical noise in MS? We are using a LCQ Deca
for nanocapillary spray work and have been fighting a battle with "marching
background" at concentrations of Acetonitrile between 15-35%+. Is this
increase in noise normal, or are there options in solvent choice to
minimize it?

Thank you for your input!

Roderick McCoy
Protein Chemistry/Nucleic Acid Laboratory
Washington University in St. Louis
Box 8103
St. Louis, MO 63110
(314) 362-0283
(314 362-4698(fax)
mccoy@molecool.wustl.edu



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