oxidation of methionine

From: Hanno Steen (hanno.steen@cebi.sdu.dk)
Date: Tue May 30 2000 - 10:19:13 EDT

Hi there,
is there any protocol available to oxidise the methionine residue in peptides in a controlled way so that only the sulfoxide is obtained. I tried hydrogenperoxide (3%) and performic acid but in both cases I ended up with the sulfonyl compound (the dioxide). Any suggestions are appreciated.
Thanks in advance,
Hanno

__________________

Hanno Steen

Protein Interaction Laboratory (PIL)
Department of Biochemistry and Molecular Biology
University of Southern Denmark
Campusvej 55
5230 Odense M
Denmark
Phone: +45-65502474 (office), +45-65502470 (lab), +45-65502435 (MS-lab)
Fax: +45-65933018
email hanno.steen@cebi.sdu.dk
URL http//www.pil.sdu.dk

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