Dear Jennifer,
Leucine is quite insoluble. You should suspend it in your solvent
mixture (normally, dioxane/water with some carbonate) and add Boc2O
keeping pH at the recommended level. Leu is going to be dissolved as
the reaction proceeds. Refer to good old methodological sources (e.g.
Houben-Weil Bd.15) for details.
Have success
Vladimir
On 28/07/2000, Paul Semchuk wrote:
> Hi,
> I am trying to add the BOC group onto L-leucine (labelled) and I am
> having problems with solubility. I can't seem to find a solvent that
> leucine is soluble in (DMF, NMP, water....). If anyone out there has
> any ideas, please reply to:
> jenn.labrecque@ualberta.ca
> Thank you.
> Jennifer Labrecque
> PENCE University of Alberta
Vladimir Titov
Bokiron Ltd., Moscow, Russia
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