Dear All
I have the following two Phospho-peptides to make;
V S S D G H E Y* I Y* V D P M Q L P Y D S T
K E P E E R P T F E Y* L Q A F L E D Y
Y* = Tyr(PO(OH,OBzl))-OH
Both will be made on a pioneer Fmoc synthesiser. I was going to use
HATU .49M, DIPEA 1M activators, 20% piperidine deblock. 1hr couple for all
A.A's, with Fmoc monitoring and auto extend deblock and couple.
Anybody have anything to add/suggest that would aid in these
syntheses?
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