trypsin on Lys next to Cys

From: Andrews, David (Andrewsd@biochempharma.com)
Date: Mon Sep 18 2000 - 16:03:40 EDT

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Does anyone have any experience as to whether trypsin will cleave a lysine
that is adjacent to a cysteine that is participating in a disulfide
bond?....and I mean on either side of the Cys....that is, in the sequence
---K-C-K---, would either lysine be clipped?...

David W. Andrews
David W. Andrews, Ph. D.
Director, Analytical Research & Development
BioChem Pharma Inc.
30 Bearfoot Road
Northborough, MA 01532

508-351-1004 (voice)
508-351-9675 (fax)

andrewsd@biochempharma.com

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