EB,
Please explain your side of this issue.
Based on the proposed study, as Linda describes, I would like to participate and would like to receive a sample also.
Jay Gambee
Shriners Hospital for Children
Protein Structure Facility
Portland, OR
On Tue, 31 Oct 2000 09:02:38 -0500 Ken Williams
<williams@biomed.med.yale.edu> wrote:
> Linda,
>
> Based on your description, it seems to us that your proposed protein
> sequencing study is completely within the Mission of the ABRF
> (http://www.abrf.org/ABRF/mission.html):
>
> "The purposes of the Association of Biomolecular Resource Facilities are to
> promote and facilitate communication and cooperation among core facilities
> and research laboratories, provide research mechanisms for evaluation and
> improvement of biotechnical capabilities of core facilities and promote the
> education of facility staff, users, administrators, and other members of
> the scientific community regarding resource facility functions.
>
> A unique feature of the ABRF is the research committees that conduct
> studies to assess the capabilities of core facilities and to provide
> materials to help member laboratories evaluate themselves."
>
> No where in that Mission do we see mention of proposed studies having to
> "lead to data suitable for publication".
>
> We would like to add our names (after that of Paul Morrison) to the (we
> expect) large group of ABRF members who would like to have the opportunity,
> and in our opinion, have the right as ABRF Members to expect to be able to
> participate in a study such as that described in your note.
>
> We also would ask the ABRF Executive Board to carefully reconsider their
> decision.
>
> Kathy Stone & Ken Williams
>
> HHMI Biopolymer & Keck Foundation Biotechnology Resource Laboratory
> Yale University
>
> ____________
>
> >Date: Mon, 30 Oct 2000 20:39:15 -0500
> >From: "Morrison, Paul T." <Paul_Morrison@dfci.harvard.edu>
> >Subject: RE: Prot Seq Res Group
> >Sender: Association of Biomolecular Resource Facilities
> > <abrf-request@aecom.yu.edu>
> >To: Recipients of ABRF List <abrf@aecom.yu.edu>
> >X-Mailer: Internet Mail Service (5.5.2650.10)
> >Old-To: "'Linda Siconolfi-Baez '" <lsiconol@aecom.yu.edu>,
> > "'Recipients of ABRF List '" <abrf@aecom.yu.edu>
> >
> > Linda,
> >
> >I'm wondering what "scientific community" the EB is thinking about. I think
> >your study is well suited to the ABRF scientific community that needs this
> >yearly yardstick of the protein sequencing sample to see how improvements in
> >technology are impacting on protein analysis. A mixture that includes Edman
> >sequencable proteins as well as more difficult lower percentage proteins I
> >would think would be ideal for 2000-1 when the instrumentation for analysis
> >are so varied.
> >Are the yearly samples that research groups send out derivative, general and
> >not normally suitable for publication? Probably. Is it worth doing so that
> >ABRF facilities can see how the technology is changing and seeing whether
> >they are keeping up? I say yes. Is the data more valuable if it takes nine
> >months or more to see the light of day because it is being peer reviewed? I
> >would say it is less valuable because in nine months the techniques and
> >instrumentation have changed.
> >Is there instrumentation that allows the internal sequence to be perceived
> >from a few femtomoles? Yes. Should the protein analysis group send out a
> >femtomole sample to test these instruments only? That would generate a ton
> >of useful data.... Not.
> >
> >If you have the sample laying around, could you send me one?
> >
> >And since I've just donned my asbestos suit I feel safe in throwing in my
> >two cents again about making the abrf discussion group password protected
> >and for ABRF members only. Let's think how useful those non-paying lurkers
> >are. Are we doing it to get a few more membership dollars and miss out on
> >their expertise? Are we going to force people who don't really fit the ABRF
> >mold (whatever that is) to become ABRFers just so they can listen in on the
> >discussion group? Are we doing it to get rid of junk mailers? Are these
> >valid reasons? OK, I'm getting carried away with the questions.
> >
> >Let's have a discussion.
> >
> >Paul, (I know sequencable is not a word), Morrison
> >
> >____________________________________
> >Paul Morrison JFB216 paul_morrison@dfci.harvard.edu
> >Molecular Biology Core Facilities
> >Dana-Farber Cancer Institute http://mbcf.dfci.harvard.edu
> >44 Binney Street 617-632-3082
> >Boston, MA 02115 fax 632-4814
> >____________________________________
> >
> >
> >-----Original Message-----
> >From: Linda Siconolfi-Baez
> >To: Recipients of ABRF List
> >Sent: 10/30/00 11:15 AM
> >Subject: Re: Prot Seq Res Group
> >
> >Rebecca,
> >
> >Unfortunately, there will not be a protein sequencing study this year.
> >In the throes of the Executive Boards process of rethinking its proteomics
> >strategy,
> >and the change of the PSRG (protein sequencing research group) to the PARG
> >(protein
> >analysis) the study designed by our group was not approved by the board.
> >Their
> >criticisms of our study (which would have encouraged participants to
> >identify as many
> >components as possible from a lyophilized test sample consisting of a
> >complex mixture
> >of intact proteins, the components of variable abundancy, with two proteins
> >more
> >abundant relative to the others and identifiable by EDMAN) included that
> >they
> >"did not feel that it would lead to data suitable for publication as the
> >subject was
> >too general, did not ask sufficiently well defined questions and would not
> >return
> >data that would have any statistical significance or impact on the
> >scientific
> >community."
> >I also regret the EB's decision to dissolve our group at ABRF'01 (at
> >which point our efforts thus far will have served for naught) as part of an
> >ongoing
> >Research Group restructuring exercise.
> >
> >Linda
> >(PARG, co-chair)
> >
> >Linda Siconolfi-Baez
> >Laboratory for Macromolecular Analysis
> >Albert Einstein College of Medicine
> >Ullman 405
> >1300 Morris Park Avenue
> >Bronx, N.Y.10461
> >718-430-2864
> >lsiconol@aecom.yu.edu
> >
> >----------
> >>From: Rebecca Ettling <ettlingr@musc.edu>
> >>To: Recipients of ABRF List <abrf@aecom.yu.edu>
> >>Subject: Prot Seq Res Group
> >>Date: Thu, Oct 26, 2000, 9:51 AM
> >>
> >
> >>Will there be a Protein sequencing study this year ? I don't see it
> >>listed.
> >>
> >>-- Rebecca P. Ettling
> >>Biotechnology Resource Laboratory
> >>Protein Sequencing and Peptide Synthesis Facility
> >>Medical University of South Carolina
> >>173 Ashley Avenue, Room 733D BSB
> >>Charleston, SC 29403
> >>Tel.: (843) 792-1271
> >>Fax: (843) 792-1264
> >>
> >>If I have seen farther than others, it is because I was standing on the
> >>shoulders of giants.--Isaac Newton
> >>
> >>
>
----------------------
Jay Gambee
JEG@shcc.org
This archive was generated by hypermail 2b29 : Thu Nov 09 2000 - 09:18:08 EST