Dear Bruce
we are experienced MALDI-TOF analysis of polymers and we got very nice
results. we tried different matrices and different conditions and on monday
(I am at home now) i will try to send you conditions, matrices and some
suggestions.
Regards
Piero
At 16.21 30/11/00 -0500, you wrote:
>I've seen a lot of great advice about MALDI-TOF MS of peptides, proteins and
>nucleic acids being provided here so I am hoping to find a little help in
>another area. We are trying to look at polymers by MALDI-TOF and have been
>having some trouble getting them to fly. Our favorite test subjects are
>commercially availble polyethyleneimine (2000 and 25,000 Da), polyallylamine
>(15,000 and 70,000 Da) dextran (60,000-90,000 Da) and chitosan (150,000 to
>540,000 Da). Now I know the highest MW compounds may be out of reach, but I
>expected to be able to analyze a 2000 MW polymer. Are there any preferred
>matrices, concentrations, parameters, etc. that you can send my way? Thanks
>in advance for any information or citations!
>
>Bruce.
>
>Bruce Frank, Ph.D.
>Director, Chemistry
>ValiGen (formerly Kimeragen, Inc.)
>300 Pheasant Run
>Newtown, PA 18940
>Phone: 215-504-4444 x214
>Fax: 215-504-4545
>email: bfrank@kimeragen.com
>
>
Prof. Piero Pucci
Dipartimento di Chimica Organica e Biochimica
Universitý di Napoli Federico II
Complesso Universitario Monte S. Angelo
via Cinthia - 80126 Napoli
Tel. +39-081-674318; Fax: +39-081-674313
e
Centro Internazionale Servizi di Spettrometria di Massa
via Pansini 5 - 80131 Napoli
http://sco.technapoli.it/mass/Home.html
Tel. +39-81-5465136 Fax +39-81-5465484
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