>Hi Bruce - Here's a few options. When using volatile solvents,
>multiple spotting of a uL of the analyte on the target plate helps.
>Please let me know if you get a decent matrix for chitosan. Regards-
\Jim Kerwin
Mass Spectrometry Facility
Cornell University
Ithaca, NY 14853
Tel 607-254-4848
>
>
>At 16.21 30/11/00 -0500, you wrote:
>>I've seen a lot of great advice about MALDI-TOF MS of peptides, proteins and
>>nucleic acids being provided here so I am hoping to find a little help in
>>another area. We are trying to look at polymers by MALDI-TOF and have been
>>having some trouble getting them to fly. Our favorite test subjects are
>>commercially availble polyethyleneimine (2000 and 25,000 Da), polyallylamine
>>(15,000 and 70,000 Da) dextran (60,000-90,000 Da) and chitosan (150,000 to
>>540,000 Da). Now I know the highest MW compounds may be out of reach, but I
>>expected to be able to analyze a 2000 MW polymer. Are there any preferred
>>matrices, concentrations, parameters, etc. that you can send my way? Thanks
>>in advance for any information or citations!
>>
>>Bruce.
>>
>>Bruce Frank, Ph.D.
>>Director, Chemistry
>>ValiGen (formerly Kimeragen, Inc.)
>>300 Pheasant Run
>>Newtown, PA 18940
>>Phone: 215-504-4444 x214
>>Fax: 215-504-4545
>>email: bfrank@kimeragen.com
>>
>>
>Prof. Piero Pucci
>Dipartimento di Chimica Organica e Biochimica
>Universitý di Napoli Federico II
>Complesso Universitario Monte S. Angelo
>via Cinthia - 80126 Napoli
>Tel. +39-081-674318; Fax: +39-081-674313
>e
>Centro Internazionale Servizi di Spettrometria di Massa
>via Pansini 5 - 80131 Napoli
>http://sco.technapoli.it/mass/Home.html
>Tel. +39-81-5465136 Fax +39-81-5465484
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