Same mess with acetic anhydride. I know that dimethylamine and diethylamine
in DMF work fine in solution but afraid they react too slow for solid
phase. If having some time, I would try to play with addition of some
quaternary bases (e.g. tetrabutylammonium hydroxide) to the deprotection
cocktail.
On 13/12/2000, David A. Schooley wrote:
> Sergey-
> Piperidine is a precursor for an illicit drug; I believe it
> is phencyclidine. It is a major nuisance to buy it in the US as
> well. We have one person in our purchasing department who is the
> ONLY person on campus who may order such so-called controlled
> substances. Methylamine hydrochloride, recommended for scavenging
> the traces of cyanate in urea, is another case- precursor of
> methamphetamine. For the methylamine it is easy to switch to
> ethylamine.
> I have wondered about the feasibility of switching to
> N-methylpiperidine, which must be of similar basicity and was used as
> the coupling base in HP protein sequencers. However, I didn't think
> we should switch because with extra trouble we can order piperidine.
> David
Vladimir Titov
Bokiron Ltd., Moscow, Russia
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