Hi Michael,
One convenient method for the synthesis of homopolymers of tyrosine
or other amino acids is the polymerization of the N-carboxy anhydride
derivative of the amino acid. This technique and the properties of the
polymers obtained are described in a comprehensive review by Katchalski and
Sela:
Katchalski, E., and Sela, M. (1958) Advances in Protein Chemistry 13:242-492
Good luck.
Daniel
At 10:03 PM -0500 1/11/01, Michael Moore wrote:
>To all peptide experts:
>
>We have a request for the synthesis of a homopolymer of tyrosine and
>possibly serine. Has anyone prepared these and if so, by what method? Are
>there any references? I'd guess the purification might be difficult?
>Thanks in advance.
>
>Michael
Daniel Wellner, Ph.D.
Department of Biochemistry, Room A-284
Weill Medical College of Cornell University
New York, NY 10021
Tel: (212) 746-6409
FAX: (212) 746-8875
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