I have synthesized several peptides lately and have come up with a peak in mass spec of 163 higher in almost every one of these peptides. There has been no tyrosine in any of them. This contaminant does purify out but it is decreasing my yield. I have already checked out all common reagents to these peptides and have not found anything that has been used in all of them. Also other peptides synthesized along with these do not have the 163 extra mass so it is not in every peptide made. Does anyone have any ideas? I would really appreciate it.
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