Hi,
We are using periodate oxidation to identify an intermolecular disulfide. This works quite well, however, the reaction products appear to be cysteine sulfinic acid (2 oxygens) and cysteic acid (3 oxygens) when analyzed by MS (Q-TOF). Cysteic acid is expected, however the literature is quite sparse regarding this reaction. Has anyone observed cysteine sulfinic acid as a reaction product of this oxidation? Could cysteic acid be break down to cysteine sulfinic acid in the MS instrument?
Thank you,
Tom
***********************************************
Thomas J. Porter, Ph.D.
Principal Scientist
Biopharmaceutical Characterization
and Analysis
Genetics Institute
1 Burtt Road
Andover MA 01810
978-247-2166 (voice)
978-247-2837 (fax)
tporter@genetics.com
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