Neighboring Phosphorylation Sites

From: Michael Curtis (curtism@mail.upstate.edu)
Date: Mon Jun 11 2001 - 16:23:49 EDT

Hello.

I am currently working on a phosphorylation project and have a question
concerning neighboring phosphorylation sites. Does anyone know of an example of
two phosphorylateable residues being directly next to each other and both being
phosphorylated? Or sites that are very close?

For example:

Directly next to each other:

i.e XXSTXX giving XXSpTpXX upon phosphorylation

Or very close by:

i.e. XXS(X1-2)TXX giving XXSp(X1-2)TpXX upon phosphorylation

I am wondering if phosphorylation of one would sterically hinder the
phosphorylation of the other. Any instance of these cases that you know about or
any insight you have on this issue would be greatly appreciated.

Thanks in advance.

Mike

Mike Curtis
UMU
curtism@mail.upstate.edu

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