Message-Id: <n1359326041.92645@mac.arris.com>
Date: 9 Jan 1997 07:53:54 U
From: "Mark Dreyer" <mark_dreyer@arris.com>
Subject: MS- To charge or not
To: Recipients of ABRF List <abrf@aecom.yu.edu>
Subject: Time: 7:39 AM
MS: To charge or not Date: 1/9/97
What determines if a compound will charge or not, how well it will charge and if it will doubly charge ??
This question arises from the analysis of several compounds produced by our Combinatorial Chemistry Group which have the same peptide-like backbone but different substituting groups hanging off of the nitrogens (with the exception of the terminal amine). The groups range from straight carbon chains to multiple ring systems with and without additional nitrogens.
We, unfortunately, have not been able to analyze a large enough dataset to derive any correlation between structure and ability to charge so I am asking this question more from a theoretical standpoint.
All analysis was done by HPLC/MS using Water:ACN:HOAc:TFA (98.9:1:.1:0.02)-Buffer A and Water:ACN:HOAc:TFA (1:98.9:.1:0.02)-Buffer B
Thanks for the help,
Mark Dreyer
Arris Pharmaceutical Corp.
mark_dreyer@arris.com