Date: Thu, 16 Jan 1997 12:16:29 -0600
Message-Id: <v01530510af051e9658d9@[128.252.197.88]>
To: abrfhyp@cco.caltech.edu
From: rskubish@pharmdec.wustl.edu (Richard Skubish)
Subject: N-Me-Phe
>To: peptides@net.bio.net
>From: John.Stewart@uchsc.edu (John Stewart)
>Subject: Re: N-Me-Phe
>Date: 17 Aug 1996 12:25:56 -0700
>Sender: daemon@net.bio.net
>Nntp-Posting-Host: net.bio.net
>
>Dear Christoph:
> Boc-N-Methyl Phe has been used for very many peptide syntheses
>without major problems except for the steric hindrance, which means that
>you have to use super activation. The derivative should be adequately
>soluble in DMF.
> For a new paper on NMF peptides, see Reissmann et al., J. Med.
>Chem. 39: 929-936, 1996.
>
>John M. Stewart, Department of Biochemistry
>Univ. of Colorado Medical School, Denver, CO 80262
>Phone: 303-270-7534; FAX: 303-270-8215
>Email: John.Stewart@UCHSC.edu
>
>
>On 15 Aug 1996, Christoph Turck wrote:
>
>> We are trying to make a peptide with an N-terminal N-Methyl-phenylalanine.
>> This amino acid does not seem to dissolve to a significant extent in NMP,
>> DMF or DMSO. Can anybody recommend a good coupling solvent?
>>
>> Thanks,
>>
>> Chris (turck@itsa.ucsf.edu)
>>
>>
>>
>
Richard Skubish
rskubish@pharmdec.wustl.edu
314-362-0283
Washington University Medical School
Box 8103 - PNACL
660 S. Euclid
St. Louis, MO 63110