Message-Id: <s2de0597.098@war.wyeth.com>
Date: Thu, 16 Jan 1997 10:36:05 -0500
From: Pat Wesdock <WESDOCP@war.wyeth.com>
Subject: pepsyn
To: Recipients of ABRF List <abrf@aecom.yu.edu>
Hello again all:
Yes, Leo and other responders are correct. N-Z-L-Pyroglutamate is
commercially available. That is what we used for the synthesis which
prompted my original question. Our source was: Chemical Dynamics
Corporation in South Plainfield, NJ. PN 17-8020-00. However, I
pulled the bottle off a shelf in our chemical stockroom. It looks
quite old. I don't know if the company even exists any longer. Does
anyone else know?
Yesterday I checked the compound by esi-ms and found it to contain
the target ion (M+H = 264), but also found a more intense ion at M+H
= 220. This of course is -44 from the parent. Any suggestions what
this impurity corresponds to?
And I must say, I guess I learned a lesson here. It would have
behooved me to check the integrity of my starting materials before
using them to make a number compounds and trying to decipher the
esi-ms after the fact.
Live and Learn (motto of the week)
Pat Wesdock
Wyeth-Ayerst Research
wesdocp@war.wyeth.com