Date: Wed, 22 Jan 1997 09:34:27 -0600
Message-Id: <v01530503af0ce1a11cc0@[128.252.197.88]>
To: abrfhyp@cco.caltech.edu
From: rskubish@pharmdec.wustl.edu (Richard Skubish)
Subject: Proline cis-trans isomerism
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>Date: Tue, 3 Dec 1996 11:44:22 -0600
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>From: Robert Mecham <bmecham@cellbio.wustl.edu>
>Subject: Proline cis-trans isomerism
>To: Recipients of ABRF List <abrf@aecom.yu.edu>
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>We are working with a binding protein that recognizes hydrophobic sequences
>that include proline residues (eg., VGVAPG repeats). We have found that
>the binding protein is stereo specific in that it does not recognize
>peptides where the x-P bond is in the cis configuration. Does anyone know
>what percentage of X-P bonds assume the cis isomer when one synthesizes a
>peptide like VGVAPG? Also, is there anyway to insure that all X-P bonds
>will be in the trans isomer?
>
>Thanks
>Bob Mecham
>
>
>____________________________________________________________________
>Robert Mecham, Ph.D
>
>Department of Cell Biology & Physiology
>Washington University School of Medicine
>US Post Office address:660 S Euclid Ave, Box 8228
>Shipping (FedEx) address:4566 Scott Ave
>St. Louis, MO 63110-1093
> voice: (314) 362-2254
> Fax: (314) 362-2252
> Email: bmecham@cellbio.wustl.edu
>____________________________________________________________________
>
Richard Skubish
rskubish@pharmdec.wustl.edu
314-362-0283
Washington University Medical School
Box 8103 - PNACL
660 S. Euclid
St. Louis, MO 63110