Date: Tue, 28 Jan 1997 14:11:50 -0800
From: Gottfried Proess <g.proess@eurogentec.be>
Subject: pKa of ASN side chain
To: Recipients of ABRF List <abrf@aecom.yu.edu>
Dear Mike Klein,
the pKa of the asparagine's side chain nitrogen (RCONH2 <---> RCONH(-))
is about 17 (relative to water). You may find a list of pKa of the most
common organic acids in "Advanced Organic Chemistry", Jerry March, 3rd
ed., John Wiley & Sons, pages 220-222. This type of side chains is
generally not considered in standard biology/biochemistry books due to
the low acidity of such functional groups.
I hope this helps.
Gottfried Proess
Eurogentec Bel S.A.
Parc Scientifique du Sart Tilman
B-4102 Seraing
Belgium
Tel.: + 32 4 366 61 07
Fax: + 32 4 365 51 03
E-Mail: g.proess@eurogentec.be