Date: Wed, 29 Jan 1997 15:11:24 -0800
From: Nick_Ede@cc.chiron.com (Nick Ede)
Subject: dehydr of Asp
To: Recipients of ABRF List <abrf@aecom.yu.edu>
Dear Haydn,
An excellent method for avoiding aspartimide formation is to protect
the preceeding amino acid (in this case Gly) with the Hmb backbone
protecting group. You can purchase the Fmoc protected Hmb-Gly-OH from
Novabiochem. A useful reference is Quibell etal, J.Chem.Soc., Chem.
Commun., 1994, 2343.
Kind Regards, Nick Ede
Nicholas Ede (Ph.D)
Senior Scientist
Chiron Mimotopes Pty. Ltd.
11 Duerdin St.
Clayton. 3168.
Australia.
+61 3 9565 1183
+61 3 9565 1199 (fax)
E-mail: Nick_ Ede@cc.chiron.com