Herewith some information and my thoughts on DIC - diisopropylcarbodiimide.
It has a danger associated with it that was not mentioned in the material
safety data sheets. These allude to contact causing eye irritation. But
there is more to it.
There appeared in the Nov 05-1990 issue of Chemical & Engineering News of
the AmChemSoc. a description of the effects on someone who had cleaned up a
spill of a bottle of the liquid. There was a delayed effect, 12-18 hours
later, caused by EXPOSURE TO THE VAPOUR during clean-up. The effect was mild
pain in the eyes after 4 hours that maximized 34 hours after exposure, and
was accompanied by TEMPORARY BLINDNESS. Sight was gradually restored over
two weeks. So the danger is far from trivial.
I dont know what the MSD SHEETS recommend. My own knowledge about DIC or any
carbodiimide would lead me to wash the area on which the DIC had been
spilled with dilute acetic acid, which reacts to destroy the diimide, not
instantly, but within minutes.
Good luck. NLB
On 02:28 PM 98/1/14 +0100, you wrote:
>I am going to work with peptide synthesis and
>will among others use the reagents
>diisopropylcarbodiimides, piperidine,
>dimethylaminopyridine and anisole.
>My question is, does anybody have any suggestions
>how to handle the chemical waste of these products,
>and is there any chemiclas that can be used if you
>spill any of these reagents.
>
>Best regards
>
>Maria Thyboll
>Maria Thyboll
>Department of Analytical Chemistry
>Royal Institute of Technology
>Teknikringen 36
>100 44 Stockholm
>SWEDEN
>Tel +46 8 7906410
>Fax + 46 8 108425
>Email k93_mtl@k.kth.se
>
>
N. Leo Benoiton
Department of Biochemistry
University of Ottawa
Ottawa, Ontario, Canada K1H 8M5
Tel: 613 562 5800, Ext. 8216
Fax: 613 562 5440
eMail: benoiton@uottawa.ca