1. I think one should be careful not to overreact to a situation. DIC is
certainly a good reagent, introduced because it has properties (the
dialkylurea is soluble) that are different than those of DCC. The reality is
you should not spill the bottle on the bench or floor. This is the same
thing that one should not do with many other reagents that are in common use.
2. The hazards of skin sensitivity, dermatitis and allergic reactions are
DEFINITELY associated with the use/contact with DCC - dicyclohexylcarbodiimide.
However, I was not aware that this holds for DIC also. I ask Richard
Laursen if he is certain of his statement, so that we can all be sure about
what we are dealing with.
Sincerely yours. NLB.
At 08:53 AM 98/1/15 +0100, you wrote:
>Dear Mr Benoiton!
>
>Thank you for your answer concerning DIC.
>I have heard the bad things about DIC and I
>deliberate with myself about wether I am going
>to work with it or not. I have been thinking of
>maby using HBTU/HOBT/DIEA instead.
>Your information further confirm what I have feared.
>Thank you once more.
>
>Yours Sincerely
>Maria Thyboll
>Maria Thyboll
>Department of Analytical Chemistry
>Royal Institute of Technology
>Teknikringen 36
>100 44 Stockholm
>SWEDEN
>Tel +46 8 7906410
>Fax + 46 8 108425
>Email k93_mtl@k.kth.se
>
N. Leo Benoiton
Department of Biochemistry
University of Ottawa
Ottawa, Ontario, Canada K1H 8M5
Tel: 613 562 5800, Ext. 8216
Fax: 613 562 5440
eMail: benoiton@uottawa.ca