Re: Pep syn: PyBOP

fred_pratt@pbio.com
Tue, 20 Jan 98 12:49:54 -0500


Hi Maria,

If we were going to add Fmoc Beta Ala to a Hydroxyl functionalized
solid support, we would use:

4 equivalents of diisopropylcarbodiimide

4 equivalents of Fmoc Beta Ala (OH)

0.4 equivalents of DMAP

reaction time of 1 hour

normally you would be concerned about racemization, but that is not an
issue with Beta Ala.

Hope This Helps
Fred Pratt
PBIO