High Sensitivity Protein Identification

Kenneth Williams (Kenneth.Williams@yale.edu)
Thu, 22 Jan 1998 16:00:03 -0500

I'm looking for references/unpublished observations for extremely high
sensitivity MS or MS/MS protein identification - at or below the low amol
level - to help one of our users who would like to propose (in a grant
application) identifying some proteins at very low levels. My guess is
MALDI/peptide mass searching is the most sensitive approach but perhaps I
am wrong. Any help would be appreciated.

Thanks very much,

Ken Williams
Yale/Keck Labs