Re: High Sensitivity Protein Identification
Gary Hathaway (hathaway@cco.caltech.edu)
Fri, 23 Jan 1998 03:09:32 -0700
At 2:00 PM -0700 1/22/98, Kenneth Williams wrote:
> I'm looking for references/unpublished observations for extremely high
>sensitivity MS or MS/MS protein identification - at or below the low amol
>level - to help one of our users who would like to propose (in a grant
>application) identifying some proteins at very low levels. My guess is
>MALDI/peptide mass searching is the most sensitive approach but perhaps I
>am wrong. Any help would be appreciated.
>
> Thanks very much,
>
> Ken Williams
> Yale/Keck Labs
Ken,
you might have a look at Zhang, Andren and Caprioli, JMS Letters
1768-1771, 1995.
--------------------------------------------------
Gary M. Hathaway, Director
PPMAL - Protein/Peptide Micro Analytical Laboratory
California Institute of Technology
139-74, Division of Biology
Pasadena, CA 91125
http://www.cco.caltech.edu/~ppmal
email Gary: hathaway@caltech.edu
email facility: ppmal@caltech.edu
phone: lab (818) 395-6388 or office (818) 395-2769
FAX (818) 449-3414
-------------------------------------------------