The TFA salt form of peptides should not affect the biological activity.
However, for clinical trials, most pharmaceutical companies would like to
change it to the acetate form.
Anita
AnaSpec, Inc.
2149 O'Toole Avenue, Suite F
San Jose, CA 95131
(408)452-5055 (phone)
(408)452-5059 (fax)
e-mail: service@anaspec.com
home-page: www.anaspec.com
-----Original Message-----
From: Jean Lucchetti <j.lucchetti@eurogentec.be>
To: Recipients of ABRF List <abrf@aecom.yu.edu>
Date: Monday, February 16, 1998 4:28 AM
Subject: Peptide counterions and biological activity
>Usually after HPLC purification of our peptides we end with TFA salts. I
>wonder if using these peptides as they are instead of the corresponding
>acetate or hydrochloride can lead to significant modifications of the
>response in biological assays like for instance receptor stimulation?
>I'd appreciate any comments or references. Thanks,
>--
>Jean LUCCHETTI, Ph.D.
>EUROGENTEC Bel S.A.
>Parc de Recherche Cense Rouge
>B-4102 SERAING (BELGIUM)
>Fax : (+ 32) 4 367 45 00
>E-mail : <mailto:j.lucchetti@eurogentec.be>
>Web site : <http://www.eurogentec.be> <----check it out !
>
>