Re: cyclic peptide synthesis

Ron Kasher (ronk@cc.huji.ac.il)
Fri, 27 Feb 1998 13:54:36 +0200 (GMT+0200)

Dear Chiara,
you must give us the sequence of the peptide, at least the fitst three
residues; there are some nice tricks, specially if you have a C-terminal
AA which has a functional side chain. You can use for instance
N-Fmoc-Asp-O-Allyl (free carboxy side chain), attach it to the resin, and
deprotect the Allyl group just before the cyclization.

Good luck,
Ron Kasher.

On Thu, 26 Feb 1998 Chiara.Tarantino@com.area.trieste.it wrote:

> We have to synthesize a ten a.a. peptide with a cycle in between.
> This cycle is a lacton linking the carboxy-terminal residue with the
> side-chain -OH of a Tyrosine in position 3. Since literature
> hasn't helped us , we are looking for suggestion on how to accomplish
> such synthesis. Any comment is welcomed.
> Thanks.
> Chiara Tarantino
>

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Ron Kasher
Department of Organic Chemistry
The Hebrew University of Jerusalem
Jerusalem, 91904 Israel.

Tel: 972-2-658 6181
Fax: 972-2-658 5345
e-mail: ronk@cc.huji.ac.il