Pep. Syn. EDT/DTT

Breslav, Michael [PRI] (MBreslav@prius.jnj.com)
Mon, 16 Mar 1998 18:07:41 -0500

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And not only odor. I know at least one significant difference between
DTT and EDT -- EDT readily reacts with benzophenone (or Bpa) , but DTT
not. This is the reason why EDT can not be used for scavenging during
the TFA cleavage of the Bpa contained peptide. But, from the other
side, is DTT as good as EDT? Did anybody test and compare the efficiency
of DTT as a scavenger to EDT? I have a concern that EDT may be more
efficient than DTT. An often trade-off.
Michael Breslav
R.W. Johnson PRI
Spring House, PA 19477-0776
(215) 628 5761

> ----------
> From: anaspec[SMTP:anaspec@shell11.ba.best.com]
> Sent: Monday, March 16, 1998 1:07 PM
> To: Recipients of ABRF List
> Subject: Re: Pepsyn: Rainin symphony
>
> Dear Henriette,
>
> To avoid odor from EDT, we have changed to DTT. DTT is a solid and
> the
> smell is much less compared to EDT.
>
> Anita Hong
>
> AnaSpec, Inc.
> 2149 O'Toole Avenue, Suite F
> San Jose, CA 95131
> (408)452-5055 (phone)
> (408)452-5059 (fax)
> e-mail: service@anaspec.com
> home-page: www.anaspec.com
>

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