Try ordering 18^0 water from either Aldrich (250mg or 1g sizes) or
Fluka (1g size only) both sources claim 95 atom % 18^0.
good luck,
Paul
>In a recent paper, the authors used O-18 water in their enzymatic
>hydrolysis, in order to label the c-terminal carboxylic acid. Using this
>technique, followed by LC/MS/MS, they noted that the b-ions are easy to
>identify and discriminate from the y-ions, which can be a big help.
>Unfortunately, they say they bought O-18 water from "Miles
>Laboratories," but we have no catalog from Miles, and just cold-calling
>them wasn't too fruitful, as they are a big company, and one part
>doesn't seem to know what the other part is up to. So, I am hoping some
>ABRF person has the appropriate number to call, and the appropriate name
>for this stuff. Deuterated water is "deuterium oxide," but what do you
>call O-18 water?
>
>The paper is "De Novo peptide sequencing in an ion trap mass
>spectrometer with 18-O labeling" by Jun Qin, C. J. Herring, and Xiaolong
>Zhang
>in Rapid Communications in Mass Spectrometry 12, 209-216 (1998).
>Thanks!
>David W. Andrews, Ph.D.
>Principal Scientist, Bioanalytical Group
>Astra Research Center Boston
>128 Sidney Street
>Cambridge, MA 02139
>
>617-234-2608 (voice)
>617-576-3030 (fax)
>e-mail: david.andrews@arcb.us.astra.com
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Paul T. Jedrzejewski, Ph.D.
Barnett Institute
341 Mugar Bldg.
Northeastern University
360 Huntington Ave.
Boston, MA 02115
phone: 617.373.2857
fax: 617.373.2855 http://www.barnett.neu.edu
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