PEPSYN: C-terminal methyl ester

Henriette Remmer (remmer@staff.uiuc.edu)
Mon, 27 Apr 1998 11:44:13 -0500

Dear all:

A client requests a short peptide with a C-terminal methyl ester. The
peptide will be synthesized by standard Fmoc soli phase technique.
Is there a reliable protocol/method to esterify concurrently to cleavage
from the resin or is it preferrable to esterify the side chain protected
peptide in solution after resin cleavage?

Thanks in advance for your input.

Henriette

Dr. Henriette A. Remmer, Director
Protein Science Facility, Biotechnology Center
University of IIllinois
311 Noyes Laboratory Box 62-1
505 S Mathews Ave
Urbana, IL 61801
phone: (217)333-4695; fax: (217)244-1142
email: remmer@uiuc.edu
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