Re: peptide polymer

Nick_Ede@cc.chiron.com
Wed, 15 Jul 1998 11:28:09 -0700

Chris,

A particularly clean method of polymerising peptides was developed by
Dave Jackson's group from the University of Melbourne, Australia. It
involves capping the N-terminus of the peptide with acryoyl group
followed by simple ammonium persulfate induced polymerisation. The
size of the resulting polymer can be estimated by gel permeation
chromatography.

See O'Brien-Simpson etal., J. Am. Chem. Soc., 1997, 119, 1183-1188.

Kind Regards,

Nick Ede, Chiron Technologies

______________________________ Reply Separator _________________________________
Subject: peptide polymer
Author: Christoph Turck <turck@itsa.ucsf.edu> at SMTP
Date: 14/7/98 16:27


Can anybody recommned a procedure for making peptide polymers from a
monomeric peptide, i.e. NH2-ABCDEF-COOH ---> NH2-(ABCDEF)n-COOH? Also, is
there any way controlling the size of the product mix?

Thanks,

Chris (turck@itsa.ucsf.edu)