It is my humble opinion that you do not have to worry about the stability of
a p-nitroanilide. What you would have difficulty with is trying to get it
off. I am confident it is about as stable as any substitution group that you
will be able to think of.
Leo Benoiton
At 10:50 PM 98/7/20 -0600, you wrote:
>hello all,
>
>has anyone had any experience with a glu-gamma-para nitroanilide in fmoc
>chemistry? i have a customer requesting this as a c-terminal group on a
>six-mer. i am concerned about how it will withstand synthesis and
>cleavage conditions.
>
>any help is always much appreciated,
>
>thank you in advance
>
>jane
>
>****************************************************
>*Jane Nagel MSc (Med Chem), BSc Pharm *
>*BioTools Inc. Laboratory Services *
>*E-mail: jane@biotools.com *
>*Mobile phone:403-906-0284 *
>*Lab phone/fax:403-432-6461 *
>****************************************************
>
>
N. Leo Benoiton
Department of Biochemistry
University of Ottawa
Ottawa, Ontario, Canada K1H 8M5
Tel: 613 562 5800, Ext. 8216
Fax: 613 562 5440
eMail: benoiton@uottawa.ca