Re: PepSyn:Orthogonal protection of Lys
David A. Schooley (schooley@unr.edu)
Wed, 19 Aug 1998 16:19:58 -0700
Roger-
We considered the Dde group, but it has the disadvantage that the
2% hydrazine/DMF which removes it also removes the FMOC, leaving two
exposed amino groups. This could be OK, except the requestors want to
incorporate TWO Lys residues, each to be tagged with a different
fluorophore.
>for orthogonal protection of lysine. It's very stable to most other things
>Good luck,
>
>Roger
>
David
David A. Schooley
Dept. of Biochemistry/330
Univ. of Nevada
Reno, NV 89557
schooley@med.unr.edu
tel: (702) 784-4136; fax (702) 784-1419