RE: NHS-ester Hydrolysis
Breslav, Michael [PRI] (MBreslav@prius.jnj.com)
Wed, 26 Aug 1998 12:04:28 -0400
Just add some water. But in this case you also may get some of the methyl
ester as a by-product. Can you avoid alcohols?
Just use KOH/water + dioxane(or THF).
Michael Breslav
R.W.Johnson PRI
Spring House, PA
> ----------
> From: Dan Sillence[SMTP:sillence@dds.nl]
> Sent: Wednesday, August 26, 1998 11:07 AM
> To: Recipients of ABRF List
> Subject: NHS-ester Hydrolysis
>
>
>
> Dear All
>
> I have a NHS-ester of hexanoic acid and would like to hydrolyse it to
> liberate the hexanoic acid. I have had a go at methanolic KOH but this did
> not seem to work. What else could I try?
>
>
> Dan
> Dan Sillence
> Marie Curie Fellow
> Amsterdam Medical Center
> University of Amsterdam
> Meiberdreef 15
> Netherlands
>
> 31 20 5664948
> 31 20 6974156
>