TBTU) 1person out of 4 had very severe allergic reaction, same as you
described, with breathing difficulty. At first this was happening after
some hours from the exposure (during the evening) then becoming
hyperallergic, after few minutes, for this reason TBTU is no more in use
in our lab.
HATU) 5 out of 6 have become progressively allergic to this reagent. The
effect is a severe sort of cold, rhinitis, with severe cough. Despite
that we keep using it because of its superior performance and we have
now a special balance inside a hood for weighing and we handle it very,
very carefully, using masks and gloves, and try to keep it in solution.
By doing that we succeed in avoiding allergy.
HBTU) we had been working with this for maybe 1 year some time ago.
Noone out of 4 developed any allergy.
Moreover I must say I'm the one in the lab who develops the most severe
respiratory problem against TBTU and HATU, although I had never
developed in my life any allergic reaction against any common known
antigen.
Elisabetta Bianchi
-----------------
Elisabetta Bianchi
IRBM P. Angeletti
Department of Chemistry
via Pontina km 30,600
00040 Pomezia (ITALY)
tel +390691093434
fax +39069109225
email: bianchi@irbm.it
> Dear All
>
> Firstly we are well aware of the dangers of HBTU and it's potential effects
> on the respiratory system and our lab does everything it can to minimise
> the possibility of this occuring.
>
> We are wondering if anyone else has had a person(s) in their Laboratories
> become hyperallergic to HBTU.
>
> We have and this person only has to enter the lab sometimes and will begin
> to sneeze. Trace contacts gives severe respiratory reactions (ie become
> extremely difficult to breathe) and swelling at contact point. This
> person has worked in our labs for sometime now and has only recently (last
> couple of months) become this severerly reactive to HBTU. We are of
> course moving her onto other areas of endevour within our laboratories.
>
> So far no body else in the lab has been affected in this way desipte
> working as long or longer with HBTU. We would appreciate knowing if there
> have been cases in other labs where this has occurred.
>
>
> And lastly
> Thank you to those people who replied to the request about converting the
> ABI430A to PC control. We considering our possibilities.
>
> With many thanks
> Steve
>
> +++++++++++++++++++++++
> Stephen Love
> Centre of Drug Design and Development.
> University of Queensland
> St Lucia
> Brisbane 4072
> Queensland
> Australia.
>
> Ph (617)-3365-1097
> Fax (617) 3365-1990
> S.Love@mailbox.uq.oz.au
>