FW: Peptide Synthesis/ HBTU allergic reaction.

Everson, Anita [PRI] (AEverson@prius.jnj.com)
Thu, 10 Sep 1998 13:57:27 -0400

We have not had any problems with HBTU or HATU yet, but we have had one case
of severe allergy to DCC/HOBt. This individual spilled some dissolved
DCC/HOBt on his skin and displayed an allergic reaction a few hours later.
After that, he couldn't go anywhere near the synthesis machines where the
DCC/HOBt was in sealed bottles or he would have breathing difficulties.
Perhaps the same is true with the other coupling reagents.

Anita Everson
Peptide Lab
RW Johnson PRI, La Jolla
aeverson@prius.jnj.com

> ----------
> From: Steve Love[SMTP:S.Love@mailbox.uq.oz.au]
> Sent: Thursday, September 10, 1998 11:14 PM
> To: Recipients of ABRF List
> Subject: Peptide Synthesis/ HBTU allergic reaction.
>
> Dear All
>
> Firstly we are well aware of the dangers of HBTU and it's potential
> effects
> on the respiratory system and our lab does everything it can to minimise
> the possibility of this occuring.
>
> We are wondering if anyone else has had a person(s) in their Laboratories
> become hyperallergic to HBTU.
>
> We have and this person only has to enter the lab sometimes and will begin
> to sneeze. Trace contacts gives severe respiratory reactions (ie become
> extremely difficult to breathe) and swelling at contact point. This
> person has worked in our labs for sometime now and has only recently (last
> couple of months) become this severerly reactive to HBTU. We are of
> course moving her onto other areas of endevour within our laboratories.
>
> So far no body else in the lab has been affected in this way desipte
> working as long or longer with HBTU. We would appreciate knowing if there
> have been cases in other labs where this has occurred.
>
>
> And lastly
> Thank you to those people who replied to the request about converting the
> ABI430A to PC control. We considering our possibilities.
>
> With many thanks
> Steve
>
> +++++++++++++++++++++++
> Stephen Love
> Centre of Drug Design and Development.
> University of Queensland
> St Lucia
> Brisbane 4072
> Queensland
> Australia.
>
> Ph (617)-3365-1097
> Fax (617) 3365-1990
> S.Love@mailbox.uq.oz.au
>
>