I have not examined the details of this, but the paper given below says
"Peptides can be easily synthesized .. in solution without any purification
... Alloc-removal ...in aqueous medium ... by .. water-soluble palladium
catalyst..
Sandrine Lemaire-Audoire, M. Savignac &, Tetrahedron Lett. vol 38, pp
2955-2958 (1997).
Sincerely yours. NLB
At 12:47 PM 98/9/29 +0000, you wrote:
>Hi there!
>I have the following problem, could anybody be of any help?
>I am working on the protection of an hydroxy-aminoacid in solution.
>I've temporarily blocked the carboxy function with the allyl group, but
>after the protection of the hydroxy chain, I must remove the allyl
>ester.
>In SPPS the Pd(Ph3P)4 soluble catalyst is available but, as I am
>working in solution, I would like to avoid this one, to save time in
>the purification process and have higher yields.
>Does anybody know about an insouble catalyst which can perform the
>same reaction and the relative procedure?
>Thanks a lot
>Luca Corte
>
>Luca.Corte@com.area.trieste.it
>
>
N. Leo Benoiton
Department of Biochemistry
University of Ottawa
Ottawa, Ontario, Canada K1H 8M5
Tel: 613 562 5800, Ext. 8216
Fax: 613 562 5440
eMail: benoiton@uottawa.ca