Chloramine T (iodobeads) and lactoperoxidase catalyse oxidative iodination
of histidine (present in angiotensin III) in addition to tyrosine. Both
amino acids can be oxidised by two iodines each; this fits with the
increase of four iodine mass to angiotensin III following iodination.
Refer to page 3.3.2 of Colligan, et al. Current Protocols in Protein
Science (John Wiley and Sons, NY) for the sites of iodination.
Hope this helps.
sebastian
Sebastian Joyce, Ph.D.
Assistant Professor
Department of Microbiology & Immunology
C6814, H107
The Pennsylvania State University College of Medicine
Milton S.Hershey Medical Center
500 University Drive
Hershey, PA 17033-0850
Telephone: 717-531-4163 (office)
717-531-4181 (laboratory)
Facsimile: 717-531-4600