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>Delivered-To: sadams@northnet.org
>Date: Mon, 09 Nov 1998 14:19:44 -0500
>From: "Joseph K. Adlerstein" <jka1@spectrumedix.com>
>Reply-To: jka1@spectrumedix.com
>Organization: SpectruMedix
>MIME-Version: 1.0
>To: Pamela Adams <scottie@cell-science.org>
>Subject: New 96/384 Capillary Electrophoresis Sequencing/Genotyping Technology
>
>Dear Dr. Adams:
>
>Your name has been indicated to us as someone whose organization should
>have very serious interest in our state of the art Sequencing/Genotyping
>instrumentation and allied technologies (disposables,packaged
>chemistries, etc). We have a 96 capillary fully automated
>sequencer/genotyper to offer immediately to groups such as yourself who
>stand at the vanguard of the Genomics area.
>
>Spectrumedix is the commercialization entity and exclusive worldwide
>purveyor of the capillary electrophoresis sequencing/genotyping
>technologies initially conceived at the Ames Laboratories and funded by
>the Human Genome Project of the United States Department of Energy. This
>technology, which is now ready for commercial implementation after
>several years of in-house development and optimization (with many
>patents issued and pending), has many fundamental, inherent advantages
>over the technologies of our competitors, viz., total automation, higher
>throughputs, data quality etc.
>
>We are now in the process of offering early access to our 96 capillary
>fully automated sequencing/genotyping technology immediately, so that
>our chosen collaborators will be able to take instant advantage of the
>enormous increases in sequencing/ genotyping throughput, while greatly
>decreasing the manpower requirements as well as the skill level of such
>manpower and, most importantly and significantly, the quantities of
>chemistries and disposables required to perform such sequencing and
>genotyping.
>
>The gene discovery/genotyping program that can be achieved with our
>instrumentation easily, far outpaces what is achievable with the
>competition's technology now. We are furthermore working on the next
>generation technology, a 384 capillary Sequencing/ Genotyping instrument
>(see the recent announcement of the US Department of Energy's grant to
>SpectruMedix for this new generation technology, attached for your
>convenience) and will make access to that technology available as well,
>to our early collaboration partners as soon as it is available in the
>not too distant future.
>
>SpectruMedix' technology has been characterized, by scientists who have
>seen it in action, as the best overall, most flexible (in terms of the
>number of diverse applications), most reliable solution for the ever
>growing demands of the Genomics, Pharmaceutical, Forensic, and many
>related arenas for such instrumentation.
>
>The SCE9600 provides to the user:
>
>HIGH THROUGHPUT AUTOMATION without the hassle. The SCE9600 injects the
>genetic samples directly from the 96 well tray they were prepared in. No
>cross contamination from sample transfer, easy capability for sample
>reruns and no additional or hidden consumables to endure. Up to six
>sample trays and six 96-well buffer trays may be housed in the SCE9600
>at one time, with a simple, fully automated carrousel/elevator layout.
>
>COMPLETE CONTROL OF THE DATA. The user is presented with several
>possibilities for data output- depending on the application. Direct,
>spectrally resolved electropherograms, wavelength specific analyses, or
>color separation processes, based on matrix deconvolution protocols are
>available. For convenience, all output data is given in standard PC
>format.
>
>CUSTOMIZE ALL ASPECTS OF THE SAMPLE ANALYSIS injection conditions,
>capillary prep, and analysis protocols are all able to be modified for
>your biochemistry demands. Set up is a snap with our intuitive
>instrument software, and any combination of protocols are saved in
>personal method files.
>
>INDEPENDENT ANALYSES whereby you can run a tray of fragment analysis
>samples with a two-dye protocol, followed immediately by a tray for
>sequencing using a 4-color protocol. Instrument method files are
>tray-specific, and the data files are available for different post-CE
>processing.
>
>CUSTOMIZE YOUR DYE SETS. Fluorescence light is recorded with
>state-of-the-art CCD technology, providing a basis for access to any of
>the genetic visible dye chemistries available. Now you can mix and match
>for your exacting needs. You can even have different dye sets running on
>the same tray!
>
>RELIABLE AND REPRODUCIBLE DATA. With continuous monitoring of the system
>you get detailed feedback during all stages of operation; capillary
>conditioning, individual capillary data during sample injection and
>electrophoresis.
>
>CAPILLARY-TO-CAPILLARY COMPARISON. Sample injection monitoring
>guarantees equivalent samples for analysis. Powerful normalization
>software provides a firm foundation for comparing intercapillary elution
>times and peak profiles.
>----------------------------------------
>General Advantages:
>
>fully automated
>highly decreased sample concentrations (2 uL minimum volumes)
>flexible dye protocols
>simple automation- no sample transfer required (no cross-contamination
>issues)
>continuous instrument feedback- all capillaries, all samples, all the
>time.
>extremely flexible software
>
>Fragment Analysis:
>
>15-minute analyses (depending on analysis protocols used)
>proprietary gel matrix for genotyping
>customized software for intracapillary comparison analyses
>not limited to four dyes
>multiple injection capability
>
>DNA sequencing:
>2 hour runs- (including ALL instrument preparation)
>novel gel matrix for sequencing
>matrix deconvolution capabilities
>----------------------------------------
>
>If you would like to learn more, a visit to our plant is the fastest way
>to bring you up to date, and I would be delighted to welcome you and
>fully explore with you the possibility of a collaboration with your
>esteemed organization. If someone other than yourself is the proper
>individual to receive such information, would you kindly indicate this
>via return email at your earliest convenience.
>
>Please contact me if you would like to pursue this opportunity.
>
>Best regards,
>Joseph Adlerstein
>--
>Dr. Joseph K. Adlerstein
>CEO and President
>SpectruMedix Corporation
>2124 Old Gatesburg Road
>State College, PA. 16803
>Phone: 814-867-8600
>Fax: 814-867-4513
>email: jka1@spectrumedix.com
>
>
>
Scottie Adams aka Pamela Scott Adams
Molecular Biology Core Facility
Trudeau Institute
100 Algonquin
Saranac Lake, NY 12983
Phone: 518-891-3080
Fax: 518-891-5126
Email: sadams@northnet.org
http://www.trudeauinstitute.org