Peptide Chemistry Organic Chemistry
Permanent Residence
229 IH-45 North, #616
Conroe, TX 77304
Tel: 409-756-9083 (H)
Gemini Biotech Ltd.
3608 Research Forest Dr.
The Woodlands, TX 77381
E-mail: eddietao@hotmail.com
Tel: 281-364-0494
Fax: 281-364-0738 (O)
CAREER OBJECTIVE: Peptide Chemist Position
PROFESSIONAL EXPERIENCE:
Design, solid and solution phase synthesises of biological peptides
(pseudobond peptides; Cys-Cys dimer; two disulfide bond peptides; cyclic
peptides; phosphopeptides, biotin-peptides; peptide-KLH conjugation;
etc) using Fmoc and t-Boc methods, structure-activity relationship
study, analysis and purification of peptides (10-50 AA, 500 mg - 30 g
crude peptides or 20 mg - 25 g purified peptides) by flash column
chromatography and RP-HPLC, etc.. Characterization of peptides by MS,
amino acid analysis and sequence analysis. These peptides referred to
Endocrinology (diabetes, hypertension); Hepatitis C Virus (HCV) and
Hepatitis E Virus (HEV) Epitopes; Luteinizing Hormone-Releasing Hormone
(LHRH) Agonists and Antagonists; Human Pancreatic Polypeptide (HPP),
PeptideYY (PYY) and Neuropeptide (NPY) Analogs; Amylin, Amylin-Salmon
Calcitonin Hybrid; Glucagon-Like Peptide-2 (GLP-2) analogs; Human
Follicle-Stimulating Hormone (hFSH) receptor peptides; etc..
Many years of experience in peptide synthesizers (ABI 430A, ABI 431A,
Beckmen 990, CS Peptide Synthesizer, Pioneer MPS Peptide Synthesis
System) and hands-on experience in organic synthetic methodologies and
skills in design, synthesis, isolation, purification and
characterization of novel organic compounds or small molecule drug
candidates, unnatural amino acids by LC, TLC, GC, HPLC, NMR, MS, UV and
IR.
A: Research Scientist - Peptide Chemistry, Jan. 1998 - Present.
Gemini Biotech Ltd., The Woodlands, TX.
B: Post-Doctoral Research Fellow, June 1994 - Dec. 1997
Peptide Laboratory, Department of Surgery, College of Medicine,
University of Cincinnati, Cincinnati, OH.
C: Post-Doctoral Research Fellow, June 1993 - May 1994
Department of Biochemistry and Molecular Biology, School of
Medicine, Indiana University, Indianapolis, IN.
D: Research Fellow, Nov. 1990 - May 1993
Department of Peptide and Endocrinology Research, Xuan Wu
Hospital, Capital Institute of Medicine, Beijing, China.
E: Research Assistant, Jan. 1986 - Dec. 1986
Institute of Beijing Medicinal Chemistry, Beijing, China.
EDUCATION:
Ph.D. in Organic Chemistry (Synthesis of Natural Products),
Institute of Materia Medica, Chinese Academy of Medical
Sciences Peking (Beijing) Union Medical College, Beijing,
China. Dec. 1986 - Oct. 1990
Thesis: "Studies on the Total Synthesis of Hainanolide".
M.S. in Organic Chemistry (Organic Synthesis and Mechanism of
Organic Reactions)
Institute of Beijing Medicinal Chemistry, Beijing, China.
Sept. 1982 - Dec. 1985
Thesis: "Studies on the Synthesis of Pinacolone----Reduction
Rearrangement of Mesityl Oxide".
B.S. in Chemistry (Organic Chemistry) Department of Chemistry,
Hangzhou University, Hangzhou, China.
Oct. 1978 - July 1982
Thesis: "Nucleophilic Substitution Reactions on Rings of
Pyridine N-Oxide Derivates and Quinoline N-Oxide".
GRANTS:
A: 1. Co-Investigator in the NIH Grant GM47122 entitled
"Structure-Activity Studies of NPY", (1993-1997), USA.
2. Co-Investigator in Biomeasure, Inc. industrial contract
entitled "Development of Therapeutics Peptides",
(1994-1998), USA.
B: 1. Co-Investigator in the Grant (No. 851670800) of 8th Five-Years
(1991-1995) Foundation of the Public Health Ministry of P. R.
China entitled "Studies and Applications of Peptide Antigens
of Hepatitis C Virus (HCV) on the Serodiagnosis of Hepatitis C
Virus (HCV) Infection", (1991-1995), P. R. China.
2. Co-Investigator in the Grant (No. 39170313) of National
Natural Science Foundation of P. R. China entitled "The
Influence of Brain Natriuretic Peptides (BNP) on Cerebral
Edema", (1992-1994), P. R. China
3. Co-Investigator in the Grant (No. F119) of Beijing Natural
Science Foundation of P. R. China entitled "The Relationship
between Angiotensin Converting Enzyme Inhibitor (ACEI)
Construction and Function ", (1990-1993), P. R. China.
C: Graduate student supported by the Grant of National Natural
Science Foundation of P. R. China entitled "Studies on the Total
Synthesis of Hainanolide", (1988-1990), P. R. China.
Publications:
1. GR231118(1229U91) and Other Analogues of the C-Terminus of
Neuropeptide Y are Potent Neuropeptide Y Y1 Receptor
Antagonists and Neuropeptide Y Y4 Receptor Agonists.
E. M. Parker, C. K. Babij, A Balasubramaniam, R. E.
Burrier,
M. Guzzi, F. Hamud, G. Mukhopadhyay, M. S. Rudinski,
Zhiyong Tao, M. Tice, L. Xia, D. E. Mullins, B. G.
Salisbury.
European Journal of Pharmacology, 1998, 349, P97-105.
2. Synthetic Human Follicle-Stimulating Hormone (hFSH) Receptor
Peptides Inhibit Binding of hFSH to Y1 Cells Expressing the
Recombinant Human FSH Receptor.
MD Nixon, Zhiyong Tao, A Balasubramaniam, AR La Barbera.
30th Annual Meeting of the Society for the Study of Reproduction,
Portland, Oregon, USA, August 2-5, 1997.
3. Development of Feeding and Y-1 NPY Receptor Antagonists.
Zhiyong Tao, F. Peng , S. Sheriff, P. Eden, J. Taylor,
W. T. Chance, A. Balasubramaniam.
Fifteenth American Peptide Symposium, Nashville, TN, USA,
June 14-17, 1997.
4. Synthesis, Structure and Antagonistic Properties of Des-Asn29
[D-Trp28,32]NPY(27-36).
A. Balasubramaniam, W. Zhai, Zhiyong Tao, Y. Huang, J. E.
Fischer, P. Eden, J. E. Taylor, L. Kar, S. D.
Samarasinghe, M. E. Johnson.
Peptides, 1996, 17 (7), P1113-1118.
5. Bis (31/31'){[Cys31, Trp32, Nva34]NPY(31-36)} is a Specific NPY
Y-1 Receptor Antagonist.
A. Balasubramaniam, W. Zhai, S. Sheriff, Zhiyong Tao, W.
T. Chance, J. E. Fischer, P. Eden, J. Taylor.
Journal of Medicinal Chemistry, 1996, 39(4), P811-813.
6. Synthesis and Binding Properties of PYY(22-36) Analogs:
Development of Potent Proabsorptive Peptide.
A. Balasubramaniam, Zhiyong Tao, W. Zhai, M. Stein, J. E.
Fischer, J. E. Taylor, P. Eden, T. Voisin, M. Laburthe,
C. D. Liu, D. W. McFadden.
Peptides: Chemistry, Structure and Biology (Pravin T. P. Kaumaya
and Robert S. Hodges, Eds.), 1996, P657-658, Mayflower
Scientific Ltd., England.
7. Synthesis of Human Growth Hormone Releasing Factor (GHRF)
Analogue with High Potential Activity.
Zhiyong Tao, Jun Xing, Zhijuan Ji, Yuhong Guo, Guangxing
Wang, Shuli Sheng.
Peptides: Biology and Chemistry (Yucang Du, James P. Tam and
Youshang Zhang, eds.), 1993, P79-80, Escom Publishers,
Leiden.
8. Studies on the Total Synthesis of Hainanolide.
Zhiyong Tao, Ph.D. Thesis.
Chinese Academy of Medical Sciences, Peking (Beijing) Union
Medical College, Beijing, China, 1990, (Chi.).
9. Studies on the Synthesis of Pinacolone ---- Reduction
Rearrangement Reaction of Mesityl Oxide.
Zhiyong Tao, Jingqi Wang, Weigang Li.
Fang Hun Yan Jiu, 1986 (3) P9-16 (Chi.).
10. GC Qualitative and Quantitative Analysis for Products from
Reduction-Rearrangement Reaction of Mesityl Oxide.
Zhiyong Tao, Jingqi Wang, Weigang Li.
Fang Hun Xue Yuan Xue Bao, 1985 (2) P32-36 (Chi.).
11. Progress in Research of Synthetic Methods of Pinacolone.
Zhiyong Tao, Jingqi Wang, Weigang Li.
Fang Hun Xue Yuan Xue Bao, 1984 (4) P45-60 (Chi.).
PERSONAL DATE: Excellent health, enjoy challenges, interested in
productivity.
REFERENCES: Available upon request.
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