Protease cleavage sites

Henry Keutmann (keutmann@helix.mgh.harvard.edu)
Mon, 25 Jan 1999 11:42:37 -0500

Firstly, thanks to all of you who responded so helpfully to my
recent inquiry about tryptophan damage upon peroxide oxidation.
Does anyone know of a compendium or review of known sites for
cleavage by protease enzymes? I'm looking for a single, relatively
up-to-date reference, beyond the scattered articles over the years in
Methods in Enzymology or the Worthington Catalog. In particular, we have a
protein that appears to be processed at one or both of the sites
...EED/EDQ/DYS... (slashes indicate sites) by human granulosa cells and/or
follicular fluid. Any ideas?
Thanks!
Henry Keutmann
Endocrine Unit, Mass. General Hospital
Tel. 617-726-3966, Fax 617-726-7543
Keutmann@helix.mgh.harvard.edu