Re: Protease cleavage sites

Mark Lively (mlively@wfubmc.edu)
Mon, 25 Jan 1999 18:08:37 -0500

Henry,
Alan Barrett has recently edited a large book on proteolytic enzymes
that TRULY fits the description "compendium." It is titled "Handbook of
Proteolytic Enzymes" and is published by Academic Press. The editors are
A. J. Barrett, N. D. Rawlings, & J. F. Woessner and it was published in
1998. The book has 1666 pages and it is truly an attempt to describe
every proteolytic enzyme currently known to man. Each entry has a
section on "Activity and Specificity." It is also expensive but may have
the data you need. It also come with a CD ROM that may be searchable
(but I am not sure what it contains.)
ML

Henry Keutmann wrote:
>
> Firstly, thanks to all of you who responded so helpfully to my
> recent inquiry about tryptophan damage upon peroxide oxidation.
> Does anyone know of a compendium or review of known sites for
> cleavage by protease enzymes? I'm looking for a single, relatively
> up-to-date reference, beyond the scattered articles over the years in
> Methods in Enzymology or the Worthington Catalog. In particular, we have a
> protein that appears to be processed at one or both of the sites
> ...EED/EDQ/DYS... (slashes indicate sites) by human granulosa cells and/or
> follicular fluid. Any ideas?
> Thanks!
> Henry Keutmann
> Endocrine Unit, Mass. General Hospital
> Tel. 617-726-3966, Fax 617-726-7543
> Keutmann@helix.mgh.harvard.edu

-- 
Mark O. Lively, Ph.D.
Professor of Biochemistry
Wake Forest University School of Medicine
Medical Center Blvd.
Winston-Salem, North Carolina 27157
Voice: 336-716-2969
Fax: 336-716-7200
email: mlively@wfubmc.edu