PEG-PS and TentaGel are not the same thing. PEG-PS (the category of resin)
simply refers to any of a number of polyethylene glycol-polystyrene graft
supports. PEG-PS (the product) is the specific version of this type of resin
developed in George Barany's laboratory and now marketed by PerSeptive
Biosystems. TentaGel (from Rapp Polymere) is a PEG-PS resin developed by
Wolfgang Rapp. There are also a number of other PEG-PS resins on the market,
for example, Biosearch Technologies supplies one called Champion resin,
NovaBiochem has their NovaGel as well as TentaGel (and perhaps other
variants), and Argonaut has one called ArgoGel. All are formualted
differently and thus have different structures and characteristics, but all
are basically PEG-PS graft supports.
As for remarks and comparisons, I would direct you to two papers that
appeared recently in J. Org. Chem. Unfortunately, at the moment I can only
find the details on one of them (oddly enough it happens to be one I worked
on): "A reinvestigation of the preparation, properties, and applications of
aminomethyl and 4-methylbenzhydrylamine polystyrene resins", J.H. Adams, R.M.
Cook, D. Hudson, V. Jammalamadaka, M.H. Lyttle, and M.F. Songster, J. Org.
Chem., 63(11), 3706-3716 (1998). The other paper was written by Bing Yan
from Novartis and apeared in JOC about the same time as ours.
I think those two papers do a much better job than I could here in comparing
the different resins, however, since you did ask I will repeat a couple of
observations here. First, I would encourage you to study the swelling data
for a prospective resin in the solvent(s) you will be using, as we have found
that to be one of the best indicators for a resin's performance. Second, you
should take care when using TentaGel (and similarly formulated PEG-PS resins)
as it is known to leach significant quantities of PEG during treatment with
TFA.
In any case hope this helps, and good luck with your work,
Mike Songster
Biosearch Technologies, Inc.
mikey@solidphase.com
work1: www.solidphase.com
work2: www.chem.umn.edu/orgs/ampepsoc
mcada002@mc.duke.edu wrote:
> ABRF members,
>
> I would love to hear your remarks/success or failure stories with
> the PEG and/or Tentagel resins. Are they indeed the same resin just
> supplied from different vendors?
>
> If you have used either or both I would appreciate your passing
> along comments especially as they pertain to usage on the Rainin
> Symphony instrument.
>
> Thanks,
>
> Millie McAdams/ HHMI Biopolymer Facility
> 919-684-2652 FAX: 919-684-5458
> mcada002@mc.duke.edu