Yes, benzoyl protection for sufhydryl has been examined.
Check Zervas & Photaki, JACS vol84, p3887, 1962
vol85, 337, 1963; vol 87, p4922, 1965.
LeoB.
At 11:59 PM 99/2/13 -0700, you wrote:
>Dear ABRFers,
>
>I am preparing peptides using a benzoylated derivative of mercaptoacetic
>acid, a cyseine analog. I have heard rumous that s-benzoyl protected
>cysteine was used as a protecting group for boc chemistry in the distant
>past. Are there any old-timers out there who confirm or deny this? I
>would appreciate any references if you have some handy.
>
>Sincerely,
>
>Gary Van Domselaar
>
>Gary Van Domselaar gvd@redpoll.pharmacy.ualberta.ca
>Faculty of Pharmacy Phone: (403) 492-4493
>University of Alberta FAX: (403) 492-5305
>Edmonton, Alberta, Canada
>
>
>
N. Leo Benoiton
Department of Biochemistry
University of Ottawa
Ottawa, Ontario, Canada K1H 8M5
Tel: 613 562 5800, Ext. 8216
Fax: 613 562 5440
eMail: benoiton@uottawa.ca