We opted for the Pioneer without the MPS addition. We now have a TWO
column capacity where both columns are run on their own circuit and are
independant of each other. This means we have doubled our synthesizer
capabilities over our mothballed 9050. The Pioneer seems less bulky than
the 9050 (to me) and is a closed system, vented into a lab hood, which
takes care of the question regarding seperate rooms or venting hoods. One
word of caution:
The valves are not compatable with all organic solvents, but they might be
fixing this problem as we discuss the problem right now....
Saskia Milton
Dept Mol Biol & Biochem
U C Irvine
On Thu, 15 Apr 1999, alessandro tossi wrote:
> Hello everyone,
>
> I have been following the recent debate on peptide synthesizers with
> interest. I am a long time user of the 9050, and I agree with the fact
> that it is an easy to use, robust and easy to fix machine, and it
> synthesized all our peptides successfully. Unfortunately, the spare
> parts problem is becoming difficult to deal with. We now have some money
> to buy a new machine and were thinking of the Perseptive Pioneer
> machine. However, some of the comments I read on this machine, and
> particularly the MPS option are a bit worrying. Could users of this
> machine tell me what the principal problems are? Are there other viable
> alternatives in the price range? I should mention that we are not a
> service facility, so that the machine would not be too intensely used.
> Our peptides are in the 10-40 residue range., but we also suynthesize
> short peptides in solution, with unusual chemistries that we would like
> to do in solid phase. One final consideration; we have severe space
> problems. Could someone rate synthesizers from the "steric" point of
> view (I know this sounds silly, but finding a seperate room for the
> machine would be a problem for us, and in the lab it probably needs to
> be run in some kind of vented hood).
>
> Thanks for any advice, Alex
> ======================================================================
> Dr. Alessandro Tossi
> Dept. of Biochemistry, Biophysics and Macromolecular Chemistry
> University of Trieste
> Phone -- 39 40 6763673; Fax -- 39 40 6763691
> email: tossi@bbcm.univ.trieste.it
> tossi@univ.trieste.it
> http://www.bbcm.univ.trieste.it/~tossi
> =====================================================================
>